We do not run our own clinical trials. What we do is read the ones that already exist — and translate the best of them into supplements that actually match the dosing the research used.
FOUNDATIONS/Three pillars
Everything iriglow makes serves one of three systems.
Metabolic health is the root system for everything else. When glucose response is stable, energy is clean, inflammation is low, and the body has the raw material it needs to recover. We target three levers — AMPK activation, insulin receptor sensitivity, and mitochondrial fuel — with ingredients that have multiple decades of human trials behind them.
The gut lining is where the immune system and the outside world meet. When that barrier is intact and the microbiome is diverse, the whole body benefits — regularity, skin, mood, immune resilience. We rebuild from three angles: populate (multi-strain probiotics), repair (glutamine, zinc-carnosine), and balance (omega-3 to quiet inflammation).
NAD+ is the coenzyme that powers hundreds of metabolic reactions — and it declines roughly 50% between age 20 and 50. Restoring NAD+ (via NMN) while activating sirtuins (via trans-resveratrol) supports the cellular machinery that drives repair, recovery, and healthy aging. Omega-3 protects membrane fluidity on the same cells.
What to watch
NAD+ blood levels
Recovery time from exertion
Cardiovascular markers
Cognitive endurance
METHOD/How we choose ingredients
Six rules, one honest filter.
The supplement industry is full of products that take an ingredient with strong research, then dose it at 10% of what the research used. We refuse that game.
Human trials, not rodent studies
We require at least one well-designed human trial before an ingredient makes the formula. Petri dish and rat work is interesting, not sufficient.
Clinically studied doses
If a paper showed 500 mg berberine 3×/day worked, we don't dose 50 mg and pretend. Doses match the research — or we don't include the ingredient.
Mechanism-first
Every active has to map to a named physiological pathway. No trending ingredients without a mechanistic story that holds up under review.
Form matters
Bioavailability is the whole game. Trans-resveratrol not mixed resveratrol. NMN not niacin. Chromium picolinate not chromium chloride.
Third-party verification
Every batch is tested by an independent lab for identity, potency, heavy metals, and microbiology. Certificates of Analysis available on request.
No proprietary blends without the list
Where a 'blend' exists, we publish the ingredient names and their ratios. Hidden dosages hide ineffective dosages.
EVIDENCE/Every study we cite
The full reading list.
Every study that informs what's in an iriglow bottle. Linked to PubMed, reviewed annually, updated when new data appears.
On Berberine
In a 3-month RCT of 36 adults with type 2 diabetes, 500 mg berberine 3×/day produced HbA1c and fasting glucose reductions comparable to metformin.
Yin J, Xing H, Ye J. Metabolism. 2008;57(5):712-717.PubMed
On Berberine
Meta-analysis of 27 RCTs (n=2,569) found berberine significantly reduced total cholesterol, LDL-C, and triglycerides.
Koppen LM, et al. J Evid Based Complementary Altern Med. 2017;22(4):956-968.PubMed
On Blood Sugar Support
RCT in 180 adults with T2DM: 1,000 mcg chromium picolinate/day significantly improved HbA1c and fasting glucose after 4 months.
Anderson RA, et al. Diabetes. 1997;46(11):1786-1791.PubMed
On Blood Sugar Support
Meta-analysis of 10 RCTs: cinnamon (1-6 g/day) reduced fasting glucose by an average of 0.49 mmol/L.
Allen RW, et al. Ann Fam Med. 2013;11(5):452-459.PubMed
On Fat Burner with MCT
Meta-analysis of 13 RCTs: replacing long-chain fats with MCT produced significant reductions in body weight, waist circumference, and body fat.
Mumme K, Stonehouse W. J Acad Nutr Diet. 2015;115(2):249-263.PubMed
On Fat Burner with MCT
Meta-analysis of 11 RCTs (n=1,243): catechin-rich green tea with caffeine significantly reduced body weight and waist circumference vs placebo.
Hursel R, et al. Int J Obes (Lond). 2009;33(9):956-961.PubMed
On NAD+ Supplement
10-week RCT in 25 prediabetic women: 250 mg NMN/day increased muscle insulin sensitivity and signaling.
Yoshino M, Yoshino J, et al. Science. 2021;372(6547):1224-1229.PubMed
On NAD+ Supplement
Systematic review of 7 NMN human trials: 250-900 mg/day reliably raised blood NAD+ levels with a favorable safety profile.
Kim MH, Kim H. Int J Mol Sci. 2017;18(5):1051.PubMed
On Resveratrol
30-day RCT in 11 healthy obese men: 150 mg/day trans-resveratrol produced calorie-restriction-like metabolic, liver, and inflammatory improvements.
Timmers S, et al. Cell Metab. 2011;14(5):612-622.PubMed
On Resveratrol
Meta-analysis of 21 RCTs: resveratrol significantly improved endothelial function (FMD) in cardiovascular-risk patients.
Fogacci F, et al. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618.PubMed
These statements reflect the published literature. They have not been evaluated by the FDA. No iriglow product is intended to diagnose, treat, cure, or prevent any disease.
