Every input,
intentionally chosen.

Not a directory of trendy compounds. Every ingredient below is in an iriglow product at the dose human research supports. Jump to any one.

All (14)Metabolic (6)Gut (4)Cellular (3)General (1)

Metabolic health.

Berberine HCl

A plant alkaloid with 40+ clinical trials. Activates AMPK, the cell's master metabolic sensor, and supports healthy glucose response, lipid profile, and insulin sensitivity at clinically studied doses.

RCT of 36 adults with T2DM: 500 mg 3×/day produced HbA1c and fasting glucose reductions comparable to metformin.

Yin J, Xing H, Ye J. Metabolism. 2008;57(5):712-717.PubMed

Meta-analysis of 27 RCTs (n=2,569) found berberine significantly reduced total cholesterol, LDL-C, and triglycerides.

Koppen LM, et al. J Evid Based Complementary Altern Med. 2017;22(4):956-968.PubMed

Dose: 500 mg
Form: Granular Berberine Hydrochloride Extract (8% bark/root + 97% bark)
Source: Bark and root extracts of Phellodendron, Coptis, and Berberis species.

Chromium Picolinate

A mineral-chelate form of chromium with the best absorption profile. Supports insulin signaling at the receptor level — one of the most studied metabolic micronutrients.

RCT in 180 adults with T2DM: 1,000 mcg chromium picolinate/day significantly improved HbA1c and fasting glucose after 4 months.

Anderson RA, et al. Diabetes. 1997;46(11):1786-1791.PubMed

Dose: 140–200 mcg
Form: Chromium picolinate (amino acid chelate)
Source: Synthesized; chromium is an essential trace mineral.

Alpha Lipoic Acid

A powerful antioxidant synthesized in mitochondria, water- and fat-soluble so it works in every cellular compartment. Regenerates other antioxidants (vitamin C, E, glutathione) and supports glucose uptake.

Meta-analyses show ALA supplementation reduces fasting glucose and improves insulin sensitivity markers in diabetics.

Akbari M, et al. Metabolism. 2018;87:56-69.PubMed

Dose: 300 mg
Form: Alpha Lipoic Acid (ALA), racemic
Source: Synthesized; naturally present in spinach, broccoli, red meat.

Cinnamon extract

Concentrated Cinnamomum cassia. Multiple RCTs show modest but reliable reductions in fasting glucose when consumed daily alongside a standard diet.

Meta-analysis of 10 RCTs: cinnamon (1-6 g/day) reduced fasting glucose by an average of 0.49 mmol/L.

Allen RW, et al. Ann Fam Med. 2013;11(5):452-459.PubMed

Dose: 250 mg
Form: Standardized extract
Source: Cinnamomum cassia bark.

MCT Oil (C8/C10)

Medium-chain triglycerides bypass standard fat metabolism to become fast ketone-friendly fuel. Supports steady energy without stimulant spikes.

Meta-analysis of 13 RCTs: replacing long-chain fats with MCT produced significant reductions in body weight, waist circumference, and body fat.

Mumme K, Stonehouse W. J Acad Nutr Diet. 2015;115(2):249-263.PubMed

Dose: 1 g
Form: C8 (caprylic) + C10 (capric) triglycerides
Source: Fractionated coconut oil.

Green tea catechins (EGCG)

The most active polyphenol in green tea. Supports thermogenesis and fat oxidation, particularly when paired with movement.

Meta-analysis of 11 RCTs (n=1,243): catechin-rich green tea with caffeine significantly reduced body weight and waist circumference vs placebo.

Hursel R, et al. Int J Obes (Lond). 2009;33(9):956-961.PubMed

Dose: 200 mg
Form: Standardized Camellia sinensis leaf extract
Source: Camellia sinensis (green tea) leaves.

Gut & immunity.

Lactobacillus + Bifidobacterium blend

A 10-strain clinical blend at 40 billion CFU, delivered via MAKTREK® delayed-release to survive stomach acid and colonize the colon — where probiotics actually need to act.

Meta-analysis of 53 RCTs (n=5,545): multi-strain probiotics significantly improved IBS symptoms vs placebo.

Ford AC, et al. Am J Gastroenterol. 2018;113(Suppl 2):1-18.PubMed

Specific probiotic strains reduce antibiotic-associated diarrhea by ~60% and acute infectious diarrhea by ~25%.

Sanders ME, et al. Nat Rev Gastroenterol Hepatol. 2019;16(10):605-616.PubMed

Dose: 40 billion CFU
Form: Shelf-stable, delayed-release capsule
Source: Fermentation-derived strains.

Organic Apple Cider Vinegar

Acetic acid plus naturally-occurring bacterial cultures. Supports healthy stomach acid production and post-meal glucose handling. In softgel form to bypass esophageal irritation.

RCT: 1-2 tbsp apple cider vinegar with a high-carb meal reduced post-prandial glycemia by ~30%.

Johnston CS, et al. Diabetes Care. 2004;27(1):281-282.PubMed

Dose: 1,000 mg
Form: Organic ACV powder, enteric-coated softgel
Source: Organic apples.

Inulin (prebiotic fiber)

A soluble fiber that selectively feeds Bifidobacterium in the colon. Supports microbiome diversity and short-chain fatty acid production.

Inulin supplementation selectively increased Bifidobacterium populations in healthy adults across multiple human trials.

Davani-Davari D, et al. Foods. 2019;8(3):92.PubMed

Dose: 500 mg
Form: Extracted inulin from Helianthus tuberosus
Source: Jerusalem artichoke tuber root.

DigeZyme® enzyme complex

A patented blend of digestive enzymes — amylase, protease, lactase, lipase, cellulase — to support breakdown of carbs, protein, dairy, fat, and plant fiber.

Multi-enzyme supplementation shown to reduce post-prandial bloating and discomfort in functional digestive disorders.

Majeed M, et al. Clin Med Insights Gastroenterol. 2018;11.PubMed

Dose: 100 mg
Form: DigeZyme® multi-enzyme complex
Source: Fungal and microbial fermentation.

Cellular longevity.

NMN

β-Nicotinamide Mononucleotide. The most direct oral precursor to NAD+, the coenzyme that powers hundreds of cellular reactions and declines ~50% between age 20 and 50.

10-week RCT in 25 prediabetic women: 250 mg NMN/day increased muscle insulin sensitivity and signaling.

Yoshino M, Yoshino J, et al. Science. 2021;372(6547):1224-1229.PubMed

Systematic review of 7 NMN human trials: 250-900 mg/day reliably raised blood NAD+ levels with a favorable safety profile.

Yi L, et al. GeroScience. 2023;45(1):29-43.PubMed

Dose: 500 mg
Form: β-Nicotinamide Mononucleotide, ≥99% pure
Source: Fermented via enzymatic synthesis.

Trans-Resveratrol

The active isomer of resveratrol. Activates SIRT1 — a longevity-associated protein that regulates cellular stress response, mitochondrial biogenesis, and DNA repair.

30-day RCT in 11 healthy obese men: 150 mg/day trans-resveratrol produced calorie-restriction-like metabolic, liver, and inflammatory improvements.

Timmers S, et al. Cell Metab. 2011;14(5):612-622.PubMed

Meta-analysis of 21 RCTs: resveratrol significantly improved endothelial function (FMD) in cardiovascular-risk patients.

Fogacci F, et al. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618.PubMed

Dose: 250–600 mg
Form: Trans-resveratrol, 50% concentrate from Japanese Knotweed
Source: Polygonum cuspidatum (Japanese Knotweed) root extract.

Quercetin Dihydrate

A plant flavonoid that inhibits CD38, the enzyme that breaks down NAD+. Protects the NAD+ you take in, amplifying NMN's effect.

Quercetin demonstrated CD38 inhibition and NAD+ preservation effects in multiple preclinical studies.

Escande C, et al. Diabetes. 2013;62(4):1084-1093.PubMed

Dose: 250 mg
Form: Quercetin Dihydrate Extract
Source: Sophora japonica (whole flower bud).

Foundational.

EPA + DHA (Omega-3)

The two long-chain omega-3 fatty acids the body uses but can't efficiently synthesize. EPA quiets inflammatory signaling; DHA composes ~30% of brain phospholipids and protects membrane fluidity.

REDUCE-IT trial (n=8,179, 4.9 years): 4 g/day icosapent ethyl reduced major cardiovascular events by 25% in statin-treated high-risk patients.

Bhatt DL, et al. N Engl J Med. 2019;380(1):11-22.PubMed

MIDAS trial (n=485, 24 weeks): 900 mg DHA/day improved memory and learning scores in adults with age-related cognitive decline.

Yurko-Mauro K, et al. Alzheimer's & Dementia. 2010;6(6):456-464.PubMed

Dose: 180 mg EPA + 120 mg DHA
Form: Triglyceride-form fish oil concentrate
Source: Wild-caught small fish (sardines, anchovies).

These statements reflect the published literature. They have not been evaluated by the FDA. No iriglow product is intended to diagnose, treat, cure, or prevent any disease.

Every input,intentionally chosen.