In a 3-month RCT of 36 adults with type 2 diabetes, 500 mg berberine 3×/day produced HbA1c and fasting glucose reductions comparable to metformin.
Yin J, Xing H, Ye J. Metabolism. 2008;57(5):712-717.PubMed
Metabolic
60 capsules · 30-day supply
30 servings
Berberine
Supports healthy glucose metabolism.
A plant alkaloid with strong clinical evidence. Activates AMPK, a master metabolic regulator, and supports healthy glucose response, lipid profile, and insulin sensitivity.
$39.00 one-time · ships free
- Supports healthy glucose levels
- Activates AMPK pathway
- Supports healthy lipid profile
Free shipping
On first orders
30-day trial
Satisfaction guarantee
Third-party tested
Every batch
4.9 / 5
42,000+ members
Plain English. No hand-waving.
Activates AMPK, the cell's master metabolic sensor. This signals mitochondria to burn glucose more efficiently and softens post-meal spikes.
Every milligram,
on the panel.
This is the printed label on the bottle, transcribed. Compare it to anything else you take — the dosing speaks for itself.
500 mg
Berberine HCl
AMPK activation · glucose support
Supplement Facts
- Serving Size
- 2 Capsules
- Servings Per Container
- 30
Amount Per Serving
Granular Berberine Hydrochloride Extract 8% (bark/root)
790 mg
*
Granular Berberine Hydrochloride Extract 97% (bark)
10 mg
*
* Daily Value (DV) not established.
Other ingredients: Cellulose (vegetable capsule), MCC (microcrystalline cellulose), L-Leucine, Olive Oil.
Your first 12 weeks
on Berberine.
These aren't marketing promises, they're the patterns we see across thousands of members, week by week.
1
Subtle smoothing of post-meal energy. Fewer sharp afternoon dips.
2
Cravings for quick carbs soften. More stable mental focus between meals.
3
Fasting glucose and HbA1c markers trending down on standard labs.
4
Metabolic baseline reset. Energy stays clean across the day.
The actual
papers.
Activates AMPK, the cell's master metabolic sensor. This signals mitochondria to burn glucose more efficiently and softens post-meal spikes.
Meta-analysis of 27 RCTs (n=2,569) found berberine significantly reduced total cholesterol, LDL-C, and triglycerides.
Koppen LM, et al. J Evid Based Complementary Altern Med. 2017;22(4):956-968.PubMed
These statements reflect the published literature. They have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
What members say about Berberine.
4.7 / 5
Member rating
42,000+
Active members
94%
Re-order rate
"The post-lunch crash is gone. I used to hit a wall at 2pm, the kind that needed coffee and usually a sweet thing. After about three weeks on berberine the crash just… stopped."
Martín R.
Austin, TX · Member · 5 months
"HbA1c dropped from 5.8 to 5.4 between two annual physicals. My doctor asked what I was doing different. Berberine and walking after meals, that's it."
Priya S.
Seattle, WA · Member · 11 months
"Had some stomach grumbling in week 1 but it settled once I started taking it with meals. Energy is noticeably steadier now."
Dan L.
Brooklyn, NY · Member · 2 months
Reviews from verified members. Individual results vary. We don't curate reviews — we publish what comes in.
What we test for,
in every batch.
We don't outsource quality. Every batch of Berberine is independently tested before it ever reaches a bottle. Certificates of Analysis are available on request.
Confirms each ingredient matches its label.
Verifies actives are at the dose we promise.
Lead, arsenic, mercury, cadmium — all below FDA-safe limits.
No pathogens. CFU counts verified at end-of-shelf-life.
Before you start.
Specific to Berberine, plus everything about subscription, returns, safety, and how iriglow works.
With your two largest meals, ideally lunch and dinner. Berberine works best when present during a glucose excursion. Most members split 1 capsule per meal.
